Clarithromycin Stella Dosage/Direction for Use

Administration: The drug is administered orally.
Clarithromycin may be given without regard to meals as food does not affect the extent of bioavailability.
Please consider other suitable oral preparation for recommended dosages other than 250 mg or 500 mg.
Dosage: Patients with respiratory tract/skin and soft tissue infections: Adults: The usual dose is 250 mg twice daily although this may be increased to 500 mg twice daily in severe infections. The usual duration of treatment is 6 to 14 days.
Children older than 12 years: As for adults.
Children younger than 12 years: Use of clarithromycin tablets are not recommended for children younger than 12 years.
Eradication of H. pylori in patients with duodenal ulcers (Adults): The usual duration of treatment is 6 to 14 days.
Triple therapy: Clarithromycin 500 mg twice daily and lansoprazole 30 mg twice daily should be given with amoxycillin 1000 mg twice daily.
Triple therapy: Clarithromycin 500 mg twice daily and lansoprazole 30 mg twice daily should be given with metronidazole 400 mg twice daily.
Triple therapy: Clarithromycin 500 mg twice daily and omeprazole 40 mg daily should be given with amoxycillin 1000 mg twice daily or metronidazole 400 mg twice daily.
Triple therapy: Clarithromycin 500 mg twice daily should be given with amoxycillin 1000 mg twice daily and omeprazole 20 mg daily.
Elderly: As for adults.
Renal impairment: Dosage adjustments are not usually required except in patients with severe renal impairment (creatinine clearance <30 ml/min). If adjustment is necessary, the total daily dosage should be reduced by half, e.g. 250 mg once daily or 250 mg twice daily in more severe infections. Treatment should not be continued beyond 14 days in these patients.